Mum's being switched to a different medication for her blood pressure. Not by her doctor, though, and not for any medical reason. Indeed, the information she got at the pharmacy made it seem like it's the same medication only in heavier dose — only a careful comparison with the old box revealed the difference in active ingredient (from Perindopril Erbumine to Perindopril Arginine). The name change — and the change as explained in the leaflet — was from "Coversyl 8mg" to "Coversyl 10mg".
Why?
Well, apparently the patent on the old medicine was running out in a couple of months. By changing the formulation, the pharmaceutical company gets another 15 years. Evergreening, this is apparently called. There is an official benefit to the new formulation, but it's phrased so contingently ('potentially … longer expiry date') that it would seem to be limited if it exists at all.
So here's mum being forced onto a new medicine for no reason better than corporate greed.
Of course, the whole system of medicine patents suffers from one logical flaw: developing new medicines is important, but hardly the only area of medical research. How are the other areas financed? Either they are financed well enough, in which case the same mechanism can be used to finance development of new medicines; or they are not financed well, which is a real problem that needs to be solved urgently. In neither case are medicine patents of any real use to society.
⇦ Strip Uno | ⇨ Link: Copyright law in verse |
2 February 2007, 3:13 UTCcomment by Sue
Hi - I am a patient using this drug too. I wondered if your Mum was having any adverse affects? I am also on the 10mg. I am having headaches since the changeover. Interesting and very plausible view you have put forward also.
Regards, Sue.
20 April 2007, 20:15 UTCcomment by Kay
Hi, I had been on Coversyl 8mg for a few years with no ill effects. However, after switching to the Coversyl 10 mg, my Liver enzyme results went through the roof. I am not talking a little, I am talking of readings that were elevated of more that 100-200 above what they had been. After investigating to see what was causing it, there was a direct correaltion between when switching to the Coversyl 10mg and the elevation in readings. The reverse happened when I was changed off the Coversyl 10mg. It was discovered I was sensitive to the changed active ingredient 'Arginine'. So much for being told the 10 mg was exactly the same as the 8mg!!!!
27 July 2007, 8:05 UTCcomment by JT
Are you all aware that Arginine is inactive? It cant actually cause anything and is excreted unchanged? The TGA is very strict and demanded the toughest guidlines before the drug came out. I got switched from 8mg to 10mg and if you look closly the only think that has changed is the packet, also the generic is out so wheres the evergreening oh and the company is a foundation and now donates 100% of its turnover to charities and communities and also research. In case your wondering i work for a GP and get to read all the boring papers left bheind.
27 July 2007, 9:11 UTCcomment by sabik
@JT: I find that very hard to believe.
Firstly, the question isn't about Arginine, but about the difference between the two salts of Perindopril, Perindopril Erbumine and Perindopril Arginine. Salts generally have very different properties to their constituents.
Secondly, Arginine itself a semi-essential nutrient. Quite far from being excreted unchanged.
Thirdly, I find your characterisation of Servier inaccurate.
Finally, your poor orthography combined with a plaintive appeal to dubious authority isn't doing anything to aid your credibility.
22 October 2007, 14:27 UTCcomment by Aching
I was switched to the new formulation and suffered facial flushing, going bright red within several hours of taking the 5mg tablet each morning and having to cool my face with water to ease it. I put in an adverse reaction report to the TGA in Aust. Arginine is a vasodilator, not an inactive substance.
I am in my early 50's but I experienced constant shoulder myalgia and calf muscle cramps on the original Coversyl and now on the new formulation I currently have acute inflammatory arthritis of the hands, hips, knees and feet for which I am being tested and treated. I intend to change to the original formulation as soon as I can obtain it or will probably cease Coversyl.
13 December 2007, 11:46 UTCcomment by maureen
I have submitted an adverse reaction report to ADRAC and to Servier over the reformulated Coversyl. My 90yo mother experienced extreme and disabling vertigo every day she was on the new 5mg formulation. I insisted she be changed back to a generic with the 4mg erbumine salt: the vertigo gradually faded away, over a period of 5 days before she was completely free of any dizziness and woke up "feeling normal." Subsequently she has had no vertigo except for one day when she missed taking her tablet (I found it on the floor next day). About a month later she saw a specialist who decided to swap her to Atacand so the experiment will not be repeated, but watch out and let us know if dizziness is a result, and hip fractures as a result of the vertigo would be likely. Her GP initially thought this was just another symptom of old age. All ingredients are of significance, not just those the company claims to be the therapeutic ones.
21 February 2008, 10:36 UTCcomment by Aching
I have stopped the reformulated Coversyl, changing to Perindo which is now available. It has the same formulation as the original Coversyl: perindopril erbumine, not perindopril arginine. I heard from the pharmacist that Perindo was now available, but requires a replacement prescription. After a year of constant pain, within 4 days the severe myalgia stopped. And I'm not stiff and sore when I wake in the morning now. If anyone else is being crippled by muscle pain while on Coversyl, it may be a side effect.
17 March 2008, 10:11 UTCcomment by pain
I was swithched from 5mg coversyl to 10mg and I have experienced abdominal pain since {2 months}
My doctor is running tests and disreguards that
it could be a side effect. Though it is a big co-incidence. Any comments?
14 May 2008, 2:27 UTCcomment by paul
I have not taken the 'new' (arginine) formulation of Coversyl as I have a backlog of filled scripts (some are now of the 'new 'formulation), but the latest supplies, in response to a script. for Coversyl, have been changed by my pharmacist to GenRx Perindopril-4ml. perindopril erbumine. Just luck I suppose, or a wide awake pharmacist!!
17 August 2008, 5:32 UTCcomment by lance
I am 76Years of age and my doctor put me on coversyl-10 about 5 months ago, I now have a heart that is intermittent and up until coversyl had a very strong heart. I feel like I have been put through the wringer and I am about to give it the flick and go on alternative medicine. I think that the Pharmaceuticals Suck.
